Senior Principal Research Fellowship Renewal

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: A potential target for future therapy

J Ischia, O Patel, K Sethi, MS Nordlund, D Bolton, A Shulkes, GS Baldwin

2015-05-01

Objective To determine the expression and biology of the neuroendocrine growth factor gastrin-releasing peptide (GRP) and other pr..

Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo

S Kovac, SW Loh, S Lachal, A Shulkes, GS Baldwin

2012-02-15

The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of..

Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth

A Ferrand, MS Sandrin, A Shulkes, GS Baldwin

2009-03-01

Precursors of the hormone gastrin, progastrin and glycine-extended gastrin (G-gly), have been detected in colorectal polyps and tu..

Interrelationships between circulating gastrin and iron status in mice and humans

S Kovac, K Smith, GJ Anderson, JR Burgess, A Shulkes, GS Baldwin

2008-10-01

The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations ..

PAK1 interacts with β-catenin and is required for the regulation of the β-catenin signalling pathway by gastrins

H He, A Shulkes, GS Baldwin

2008-10-01

β-catenin regulates cell-cell adhesion by binding to E-cadherin at the cell membrane and, when translocated into the nucleus, medi..

Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins

H He, M Yim, KH Liu, SC Cody, A Shulkes, GS Baldwin

2008-01-01

Gastrins, including amidated gastrin (Gamide) and glycine-extended gastrin (Ggly), are known to accelerate the growth of gastric a..